Concurrent administration of ascorbic acid enhances liver tumor-promoting activity of kojic acid in rats

Concurrent administration of ascorbic acid tumor - promoting activity of kojic acienhances 1 d in rats iver

We previously fbund that administration ofascorbic ac{d (AA) enhances thc liver tumorpromoting activity ofkojic acid (KA) in rnice. To examine the reproducibility ofthese results in rats and thc underlying inechanism of this effbct, we ernployed a two-stage liver carcinogenesis model using male F344 rats. Two weeks after initiation with diethylnitrosamine (DEN), the animals received a diet cont...

Enhancement of hepatocellular proliferative activity of kojic acid in mice by a simultaneous administration of ascorbic acid.

To examine the tumor modification activity of kojic acid (KA) by sodium ascorbic acid (AA), 5-week-old male ICR mice were administered intraperitoneally with N-diethylnitrosamine (DEN) as an initiation treatment. Two weeks after the initiation treatment, animals were fed basal diet containing 0 (Group 1: DEN alone) or 3% KA (Group 3: DEN+KA), drinking water containing 5,000 ppm AA (Group 2: DEN...

Consequences of the Combined α-tocopherol, Ascorbic Acid and α-lipoic Acid on the Glutathione, Cholesterol and Fatty Acid Composition in Muscle and Liver of Diabetic Rats

Effect of intracerebroventricular administration of ascorbic acid on a seizure model induced by pentylenetetrazol in male rats

Introduction: Epilepsy is one of the most common and chronic neurological disorders. It appears periodically and usually is concomitant with unpredictable seizures due to abnormal discharge of brain neurons. In this study, we investigated the anticonvulsant effect of ascorbic acid (AA) on seizures induced by pentylenetetrazole (PTZ) in male rats. Methods: In this study PTZ (37 mg/kg) was in...

Ascorbic Acid Metabolism in Rats

1. The effect ofdietary molybdenum on the growth rate and also on ascorbic acid metabolism in rats was studied. An excess of dietary molybdenum resulted in growth retardation and loss of weight. Tolerance to molybdenum was affected by the nature ofthe molybdenum salt administered. 2. Molybdenum ingestion altered certain aspects of ascorbic acid metabolism in rats. The conversion ofD-glucuronola...